Drug Safety Update

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Finasteride and Dutasteride 鈥� updated safety warnings for psychiatric side effects and sexual dysfunction

The MHRA has reviewed the evidence for finasteride and dutasteride and the risk of suicidal thoughts and behaviours and has recommended further measures to minimise this risk.
- Therapeutic area: Dermatology and 7 others
- Published: 11 May 2026
Nasal decongestant sprays and drops containing xylometazoline hydrochloride / oxymetazoline hydrochloride: increased risk of rebound congestion, rhinitis medicamentosa, and tachyphylaxis with overuse

There have been reports of worsening nasal congestion (rebound congestion) when the effects of nasal decongestant sprays or drops containing xylometazoline hydrochloride and oxymetazoline hydrochloride, wear off.
- Therapeutic area: Dispensing GP practices and 5 others
- Published: 30 April 2026
Falsified Mounjaro KwikPen 15mg pre-filled pens

A falsified version of Mounjaro (tirzepatide) KwikPen 15mg solution for injection has been found supplied through one online pharmacy in the UK. The falsified product is labelled with batch D873576 and applies to Mounjaro Kw鈥�
- Therapeutic area: Dispensing GP practices and 5 others
- Published: 24 February 2026
Semaglutide (Wegovy, Ozempic and Rybelsus): risk of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)

Non-arteritic anterior ischemic optic neuropathy (NAION), a condition that can cause sudden deterioration in vision, usually in one eye at a time, has been very rarely reported in association with semaglutide in the treatmen鈥�
- Therapeutic area: Emergency medicine and 5 others
- Published: 5 February 2026
GLP-1 receptor agonists and dual GLP-1/GIP receptor agonists: strengthened warnings on acute pancreatitis, including necrotising and fatal cases

The product information for all Glucagon-Like Peptide-1 (GLP-1) receptor agonists and dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) receptor agonists has been further updated to highlight the potential risk o鈥�
- Therapeutic area: Emergency medicine and 5 others
- Published: 29 January 2026
Mesalazine and idiopathic intracranial hypertension

Idiopathic intracranial hypertension (IIH) has been very rarely reported in patients treated with mesalazine. Following a recent review, warnings for IIH are being added to the product information for all mesalazine products鈥�
- Therapeutic area: Emergency medicine and 4 others
- Published: 4 December 2025
#MedSafetyWeek (3-9 November 2025): A call to action to improve patient safety

The annual #MedSafetyWeek campaign takes place from 3 to 9 November 2025. This year鈥檚 campaign theme is 鈥榳e can all help make medicines safer.鈥�
- Therapeutic area: Anaesthesia and intensive care and 39 others
- Published: 23 October 2025
Paracetamol and pregnancy - reminder that taking paracetamol during pregnancy remains safe

Patients should be reminded and reassured that there is no evidence that taking paracetamol during pregnancy causes autism in children. Paracetamol is recommended as the first-choice pain reliever for pregnant women, used at鈥�
- Therapeutic area: Anaesthesia and intensive care and 34 others
- Published: 23 September 2025

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